Synthesis, in silico experiments and biological evaluation of 1,3,4-trisubstituted pyrazole derivatives as antimalarial agents
New 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their antiplasmodial activity. Compounds 4b, 4c, 7a and 7d were the most potent antiplasmodial agents against P. berghei with percent of suppression ranging from 90 to 100%. They were also screened for their in vitro antimalarial activity against the chloroquine resistant [...]
Effect of a multistrain probiotic (Lactoflorene® Plus) on inflammatory parameters and microbiota composition in subjects with stress-related symptoms
Stress affects the immune system and intestinal microbiota composition and can lead to imbalance between pro- and anti-inflammatory cytokines or to uncontrolled production of cytokines. The effect of emotional stress on secretory IgA levels also indicates that stress decreases mucosal integrity. Our aim was to evaluate whether a probiotic product [...]
Catalytic and photocatalytic properties of oxide spinels
Oxide spinels (OSs) have been identified as perspective functional materials in various fields of applications including water treatment, degradation of dyes, hyperthermia, and drug delivery and as antibacterial agent. In recent years, extensive researches are devoted to the synthesis and properties of spinel nanooxide systems to fulfill the essential requirement [...]
Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 1,2,4-triazoles
Candidates of triazole-containing amino acid derivatives 5a−k were prepared under green chemistry conditions via multicomponent reaction using lemon juice as an acidic catalyst. All compounds were characterized by different spectral and elemental analyses. They were evaluated for their in vitro antileishmanial activity against miltefosine and amphotericin B deoxycholate as reference [...]
Syntheses and in silico pharmacokinetic predictions of glycosylhydrazinyl-pyrazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]triazolo[4,3-a]pyrimidines as anti-proliferative agents
New glycosylhydrazinyl-pyrazolo[1,5-c]pyrimidines were synthesized by the reaction of respective 5-aryl-7-hydrazino-2-phenylpyrazolo[1,5-c]pyrimidines (1a-d) with glucose, galactose, and xylose in ethanol. Their glycopyranosyl structures were reasoned to be in chair conformations and each have hydrazine moiety in the β-configuration. Also, pyrazolo[1,5-c]triazolo[4,3-a]pyrimidines derivatives were synthesized by the reaction of 1a-d with benzoic acid in [...]
A novel electrochemical nanosensor based on NH 2 -functionalized multi walled carbon nanotubes for the determination of catechol-orto-methyltransferase inhibitor entacapone
In this study, an antiparkinson drug Entacapone (ENP) is electrochemically investigated under optimized conditions using NH 2 functionalized multi walled carbon nanotubes (NH 2 fMWCNT) decorated over glassy carbon electrode (GCE). The surface morphology of the NH 2 fMWCNT/GCE was probed by scanning electron microscopy (SEM) armed with EDX analysis. [...]
The impact of multilevel contextual factors on is adoption at the inter-organizational level
Inter-organizational information systems (IOIS) offer many potential benefits to organizations, and IOIS adoption has increased in the last few decades. However, IOIS adoption varies significantly across different contexts, and little research has investigated how contextual factors affect IOIS-adoption variances at the inter-organizational (IO) level in depth—particularly from a multilevel perspective. [...]
Effect of annealing on phase formation, microstructure and magnetic properties of MgFe 2 O 4 nanoparticles for hyperthermia
In this study the effect of annealing time is confirmed to alter the morphology (shape and size) of magnesium ferrite nanoparticles (MgFe 2 O 4 ) synthesized by autoclave route, employing ferric and magnesium nitrate salts as precursors. Annealing was applied at 1000 ° C for different durations (2, 30 [...]
Effects of nanoscale electric fields on the histology of liver cell dysplasia
Cells electrical fields have a significant role in cell function. Aim: The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue. Methods & results: A total of 30 nm MENs synthesized by sol-gel method were tested in vitro on HepG2 cells [...]
Is a combination of melatonin and amino acids useful to sarcopenic elderly patients? A randomized trial
This study evaluated the effectiveness of a 4-week intervention of melatonin and essential aminoacid supplementation on body composition, protein metabolism, strength and inflammation in 159 elderly sarcopenic patients (42/117, men/women), assigned to four groups: isocaloric placebo (P, n = 44), melatonin (M, 1 mg/daily, n = 42), essential amino acids [...]