Authors: Ramadan D.R., Elbardan A.A., Bekhit A.A., El-Faham A., Khattab S.N.
Author Affiliations: Ramadan, D.R., Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia Alexandria, 21321, Egypt; Elbardan, A.A., Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia Alexandria, 21321, Egypt; Bekhit, A.A., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Egypt, Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt, Pharmacy Program, Allied Health Department, College of Health Sciences, University of Bahrain, P.O. Box 32038, Bahrain; El-Faham, A., Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia Alexandria, 21321, Egypt, Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia; Khattab, S.N., Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia Alexandria, 21321, Egypt, Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt
Publication Date: 2018
A new library of dimeric s-triazine hydrazide derivatives was synthesized and fully characterized using IR, NMR, and elemental analysis. The synthesized compounds were screened for their in vitro antimicrobial activity. Some of these compounds were found to have more potent anti-bacterial activity than the standard drug ampicillin trihydrate. The compounds which showed the lowest MIC values, such as compounds 1, 12, 13, 20d, 21d and 22d, were further screened for their antibacterial activity against MDR (multi drug resistant) clinical isolates. In contrast to the reference drug ampicillin, the tested compounds revealed significantly low MIC values towards the tested MDR strains. The most active compounds 1, 12, 13, 20d, 21d and 22d showed a high selectivity index towards antimicrobial activity against K. pneumoniae and MRSA1 compared to mammalian cells, suggesting a good safety profile. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2018.
Eshan2020-11-28T18:21:00+00:00
