Noble metals are resistant to corrosion and oxidation in moist air. Ruthenium, rhodium, palladium, silver, osmium, iridium, platinum, and gold are a list of noble metals, in order of their respective atomic numbers. The unique characteristics of noble metal nanoparticles (NPs), such as high surface-to-volume ratio, broad optical properties, ease of synthesis, and facile surface chemistry and functionalization, guarantees advantages in drug analysis. The most used NPs are gold (Au) and silver (Ag) due to their electrical, chemical, optical, and other unique properties. Electrochemical methods have proven to be sensitive and reliable for the determination of numerous electroactive compounds. Under certain circumstances, electrochemical methods can offer optimal solutions for drug analysis. Simplicity, low cost, and relatively short analysis times make electrochemical techniques more useful for routine analytical applications. In this chapter, NPs and their various applications in electrochemical drug analysis are presented. © 2019 Elsevier Inc. All rights reserved.

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