Authors: Rondanelli M., Castellazzi A.M., Riva A., Allegrini P., Faliva M.A., Peroni G., Naso M., Nichetti M., Tagliacarne C., Valsecchi C., Fazia T., Perna S., Graziano F., Grassi M., Bernardinelli L.
Author Affiliations: Rondanelli, M., IRCCS Mondino Foundation Mondino.it, Italy, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Italy; Castellazzi, A.M., Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Riva, A., Research and Development Unit, Indena, Milan, Italy; Allegrini, P., Research and Development Unit, Indena, Milan, Italy; Faliva, M.A., Endocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, Pavia, 27100, Italy; Peroni, G., Endocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, Pavia, 27100, Italy; Naso, M., Endocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, Pavia, 27100, Italy; Nichetti, M., Endocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, Pavia, 27100, Italy; Tagliacarne, C., Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Valsecchi, C., Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Fazia, T., Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy; Perna, S., Department of Biology, College of Science, University of Bahrain, Sakhir Campus, P.O. Box 32038, Bahrain; Graziano, F., Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy; Grassi, M., Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy; Bernardinelli, L., Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy
Publication Date: 2019
The aim of the present study is to evaluate the effects of 60-day artichoke leaf extract (ALE) supplementation (250mg, twice daily) on cytokines levels, natural killer cell (NK) response, and lipo-metabolic profile (HDL, LDL, and total-cholesterol, triglycerides (TG), ApoB, ApoA, lipid accumulation product (LAP), glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR)) in twenty adults (9/11 males/females, age=49.10 ± 13.74 years, and BMI=33.12 ± 5.14 kg/m 2 ) with low HDL-C and mild hypercholesterolemia. Hierarchical generalized linear model, adjusted for sex, BMI, and age, has been used to evaluate pre-post treatment changes. A significant increase for HDL-C (β=0.14, p=0.0008) and MCP-1 (β=144.77, p=0.004) and a significant decrease for ApoB/ApoA (β=-0.07, p=0.03), total-C/HDL-C ratio (β=-0.58, p<0.001), and NK response at stimulus low (β=0.43, p=0.04), medium (β=0.40, p<0.001), and high (β=0.42, p=0.001) have been found. These results support the benefits of ALE supplementation on metabolic profile. © 2019 M. Rondanelli et al.
Eshan2020-11-28T18:20:01+00:00
