Authors: Javadi A.-H., Emo B., Howard L.R., Zisch F.E., Yu Y., Knight R., Pinelo Silva J., Spiers H.J.
Author Affiliations: Javadi, A.-H., School of Psychology, University of Kent, Canterbury, CT2 7NP, United Kingdom; Emo, B., Department of Cognitive Science, ETH Zurich8092, Switzerland, Bartlett School of Architecture and Design, University College London, London, WC1H 0QB, United Kingdom; Howard, L.R., Aging and Cognition Research Group, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, 39120, Germany; Zisch, F.E., Division of Psychology and Language Sciences, Department of Experimental Psychology, UCL Institute of Behavioural Neuroscience, University College London, London, WC1H 0AP, United Kingdom, Bartlett School of Architecture and Design, University College London, London, WC1H 0QB, United Kingdom; Yu, Y., UCL Centre for Advanced Biomedical Imaging, University College London, London, WC1E 6DD, United Kingdom; Knight, R., School of Psychology, University of Hertfordshire, Hertfordshire, AL10 9AB, United Kingdom; Pinelo Silva, J., Department of Architecture and Interior Design, University of Bahrain 840, Bahrain; Spiers, H.J., Division of Psychology and Language Sciences, Department of Experimental Psychology, UCL Institute of Behavioural Neuroscience, University College London, London, WC1H 0AP, United Kingdom
Publication Date: 2017
Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation. © The Author(s) 2017.
Eshan2020-11-28T18:21:34+00:00
