Effects of nanoscale electric fields on the histology of liver cell dysplasia

Authors: Balbaa A.O., El-Fattah A.A., Awad N.M., Abdellatif A.

Author Affiliations: Balbaa, A.O., Medical Research Institute, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Biology Department, School of Sciences and Engineering, American University in Cairo, New Cairo, 11835, Egypt; El-Fattah, A.A., Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt, Department of Chemistry, College of Science, University of Bahrain, Bahrain; Awad, N.M., Early Cancer Detection Unit., Ain Shams University Hospitals, Cairo, Egypt; Abdellatif, A., Biology Department, School of Sciences and Engineering, American University in Cairo, New Cairo, 11835, Egypt

Publication Date: 2019

Cells electrical fields have a significant role in cell function. Aim: The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue. Methods & results: A total of 30 nm MENs synthesized by sol-gel method were tested in vitro on HepG2 cells and in vivo on liver cell dysplasia in mice, which were exposed to 50 Hz 2 mT for 2 weeks, +/- MENs. MENs with alternating field (AF) reversed liver cells dysplastic features. In vitro cytotoxicity assay showed high lethal dose (LD 50) of 1.4 mg/ml. We also report on the expression of alpha-fetoprotein and cytochrome C. Conclusion: MEN-generated nanoscale electric fields have significant biological effects on precancerous liver cells. © 2019 Future Medicine Ltd.

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Eshan2020-11-28T18:19:27+00:00

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Effects of nanoscale electric fields on the histology of liver cell dysplasia

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