Objective: To assesses the efficacy of a hypocaloric low-carbohydrate diet ​​in overweight and obese patients with type 2 diabetes. Design: A Randomized Controlled Trial. Setting: Istituto Santa Margherita, University of Pavia, Italy. Method: Patients were enrolled based on the following criteria: both genders, age 30–85, Caucasian origin, BMI between 24.9 and 34.9 kg/m2 (overweight and obese), glycated hemoglobin ≤7.5%, glomerular filtration rate ≥60 ml/min/1.73m2 (CDK-EPI), on a free diet and only treated with metformin. Patients were evaluated before and after the intervention. They were randomly allocated to receive metformin with either a low-carbohydrate or a standard diet (control group) for 90 days. At the end of each dietary period, anthropometric and biochemical assessments, and Dual-energy X-ray absorptiometry (DXA) measurements were documented. Result: Seventeen type 2 diabetic patients with an average age of 67 years and a BMI of 31 kg/ m2 were included in the study. Eleven (64%) were females and 6 (35.3%) were males. Patients on the low-carbohydrate diet showed reduced values ​of glycated hemoglobin (-0.43%;-5 mmol/ mol; P<0, 05) both within the treated group and the control group. The preliminary data showed maintenance of fat-free mass (FFM) (-0.24 kg; p=0.862) a decrease in gynoid fat mass (FM) (-2.18 kg; P<0, 05), with a decrease in visceral adipose tissue (-0.20 kg; p=0-108). Conclusion: A low-carbohydrate low-calorie diet has a short-term effect on the assessment of blood glucose and glycated hemoglobin values. It also shows promising results in the reduction of gynoid fat and visceral fat among type 2 diabetic patients. © 2019, Bahrain Medical Bulletin. All rights reserved.

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